Endocrine Abstracts

Environmental endocrine-disrupting chemicals (EDCs) are exogenous chemicals that perturb hormones and their actions. Exposures to EDCs during critical periods of life, especially in the developing fetus and infant, are particularly problematic due to the high sensitivity of the perinatal hypothalamus to endogenous hormones and exogenous compounds. Our lab has been using a rat model of prenatal exposure to two classes of EDCs: a polychlorinated biphenyl (PCB) mixture used previ...

Environmental endocrine-disrupting chemicals (EDCs) are exogenous chemicals that perturb hormones and their actions. In our laboratory, we are studying how early life exposures to EDCs affect the developing brain and lead to behavioral dysfunctions in exposed individuals and their descendants across generations. To do this, pregnant rats are fed one of three treatments: the weakly estrogenic commercial polychlorinated biphenyl (PCB) mixture, Aroclor 1221 (A1221, 1 mg/kg); vinc...